Hypertrophic obstructive cardiomyopathy (HOCM) is an autosomal dominant disorder of muscle tissue caused by defects in the genes encoding contractile proteins. Mutations to various proteins including beta-myosin, alpha-tropomyosin and troponin T have been identified. Septal hypertrophy causes left ventricular outflow obstruction. It is an important cause of sudden death in apparently healthy individuals.
Poor prognostic factors
HOCM - poor prognostic factor on echo = septal wall thickness of > 3cm
Poor prognostic factors
- syncope
- family history of sudden death
- young age at presentation
- non-sustained ventricular tachycardia on 24 or 48-hour Holter monitoring
- abnormal blood pressure changes on exercise
HOCM - poor prognostic factor on echo = septal wall thickness of > 3cm
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