Mitral valve prolapse is common, occurring in around 5-10 % of the population. It is usually idiopathic but may be associated with a wide variety of cardiovascular disease and other conditions.
Associations
Associations
- congenital heart disease: PDA, ASD
- cardiomyopathy
- Turner's syndrome
- Marfan's syndrome, Fragile X
- osteogenesis imperfecta
- pseudoxanthoma elasticum
- Wolff-Parkinson White syndrome
- long-QT syndrome
- Ehlers-Danlos Syndrome
- polycystic kidney disease
- patients may complain of atypical chest pain or palpitations
- mid-systolic click (occurs later if patient squatting)
- late systolic murmur (longer if patient standing)
- complications: mitral regurgitation, arrhythmias (including long QT), emboli, sudden death
Whilst some patients with acromegaly have mitral valve prolapse (MVP) it is not a common association. It should be remembered that the prevalence of MVP in a standard population is around 5-10%
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